from "Truth in Aging":
Also known as Toothache plant
Acmella Oleracea extract is considered a natural alternative to Botox, and is extracted from a plant called Acmella Oleracea. Applied topically, Acmella Oleracea reportedly reduces muscle tension, reducing facial wrinkles caused by tense or contracted facial muscles. It is considered a natural muscle relaxant and has been traditionally used as an herbal Orajel of sorts, used to numb toothaches thanks to the presence of analgesic alkylamides called spilanthol. This spilanthol is thought to have the same paralyzing effects on facial muscles as it does on gums, reducing wrinkles by relaxing the skin. It’s seen in topical formulas and can easily penetrate the skin, inhibiting contractions in subcutaneous muscles. In a clinical study, 75% of patients immediately realized the smoothing effect of Acmella Oleracea, noticing results the day after the first application. Patents are being developed to use Acmella Oleracea as a safe alternative to toxic Botox. However, Acmella Oleracea does not pack the collagen-building peptide punch of the usual ‘Botox in a Jar’ ingredients (Source).
Review article: HIGH THERAPEUTIC POTENTIAL OF SPILANTHES ACMELLA